0102030405
Tetrapeptide-30 (≥95% Purity) Cosmetic Grade Peptide
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Product Description
1. Mechanism of Action (MOA)
Tetrapeptide-30 is a biomimetic peptide specifically engineered to target multiple pathways involved in periorbital hyperpigmentation (dark circles) and puffiness. Its mechanism includes:
Inhibition of Melanogenesis
Downregulates key melanogenic enzymes (e.g., tyrosinase, TRP-1) via modulation of the MITF pathway.
Reduces UV-induced and post-inflammatory pigmentation around the eyes.
Anti-Glycation Activity
Blocks the formation of advanced glycation end products (AGEs), which contribute to yellowish discoloration under the eyes.
Vascular Stabilization
Strengthens capillary walls and reduces vascular leakage, minimizing hemoglobin-derived pigmentation (hemosiderin deposition).
Lymphatic Drainage Enhancement
Promotes fluid clearance by supporting lymphatic function, reducing under-eye puffiness.
2. In Vitro Efficacy Data
Melanogenesis Inhibition: 60% reduction in melanin synthesis in human melanocytes at 10 ppm.
Anti-Glycation: 40% inhibition of AGEs formation in a cell-free assay.
Capillary Integrity: 25% enhancement of endothelial barrier function in HUVEC models.
Anti-Inflammatory: Suppression of TNF-α-induced vascular adhesion molecules (ICAM-1).
3. Clinical Results
Study Design: 56-day, double-blind trial with 45 female volunteers (35–55 years) applying a serum containing 50 ppm Tetrapeptide-2 twice daily.
Results:
Dark Circle Reduction: 30% improvement in colorimetric analysis (ITA° scale).
Puffiness: 22% reduction in under-eye volume by 3D image analysis.
Skin Brightness: 18% increase in luminance values.
Consumer Feedback: 81% of participants reported visibly brighter and less puffy eyes.
Safety
Non-irritating (HRIPT validated), non-comedogenic, and suitable for sensitive skin.
Compatibility
Stable in pH 4.5–7.5; compatible with niacinamide, vitamin C, hyaluronic acid, and most emulsifiers.
Formulation Tips
Avoid strong oxidizing agents and high concentrations of ionic surfactants.
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Recommended Usage & Dosage
Concentration: 20–100 ppm (0.002%–0.01%) in final product.
Optimal Dose: 50 ppm for clinically proven efficacy.
Applicable Products:
Eye creams, serums, gels, masks.
Brightening and anti-fatigue formulations.
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Multimodal Action
Targets melanogenesis, glycation, vascular leakage, and puffiness simultaneously.
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Clinically Validated
Proven to reduce dark circles and under-eye bags in 8 weeks.
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Safe for Delicate Skin
Designed for the periorbital area with excellent tolerance.
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Cosmetic Elegance
Water-soluble, odorless, and easy to formulate.
Storage
Store in a closed container at a dry place at room temperature.
Animal Testing
Not animal tested
Vegan
Does not contain animal-derived components
GMO
No data available